The neurobiology of auditory and visual perceptual abnormalities in a clinical high-risk for psychosis cohort: A pilot morphometric magnetic resonance imaging study

J Psychiatr Res. 2021 Oct:142:240-242. doi: 10.1016/j.jpsychires.2021.08.009. Epub 2021 Aug 10.


Our goal was to examine the neurobiology of auditory and visual perceptual abnormalities in individuals at clinical high-risk for psychosis (CHR) using morphometric magnetic resonance imaging (MRI). We enrolled 72 CHR subjects as delineated by the Structured Interview for Psychosis-Risk Syndromes (SIPS). Greater severity of visual perceptual abnormalities was associated with larger volumes in all regions tested (amygdala, hippocampus, and occipital cortex), while no relationships were observed between auditory perceptual abnormalities and brain volumes. These data support findings that while perceptual abnormalities may share a central set of neurobiological mechanisms, each type may also have distinct pathogeneses.

Keywords: Clinical high-risk for psychosis; Magnetic resonance imaging; Visual hallucinations.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Amygdala
  • Hippocampus
  • Humans
  • Magnetic Resonance Imaging
  • Pilot Projects
  • Psychotic Disorders* / diagnostic imaging