Linking microbiota composition with antimalarial antibody response

Trends Parasitol. 2021 Oct;37(10):853-855. doi: 10.1016/ Epub 2021 Aug 11.


Microbiota composition recently arose as a factor correlating with malaria infection. Mandal et al. showed, via cecal transplant and antibacterial treatment, that the mouse microbiota modulates parasitemia by affecting spleen germinal centers where B cells are matured. They further identified correlations between microbiota composition and malaria severity in Ugandan children.

Keywords: Plasmodium; malaria; microbiota; severity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Antibody Formation
  • Antimalarials* / therapeutic use
  • Malaria* / drug therapy
  • Mice
  • Microbiota*
  • Parasitemia / drug therapy


  • Antimalarials