Acute myelitis and ChAdOx1 nCoV-19 vaccine: Casual or causal association?

J Neuroimmunol. 2021 Oct 15;359:577686. doi: 10.1016/j.jneuroim.2021.577686. Epub 2021 Jul 31.


A 44-year-old previously healthy woman developed acute myelitis in close temporal relationship with ChAdOx1 nCoV-19 vaccine first-dose administration. The neurological involvement was mainly sensory with neuroimaging showing two mono-metameric lesions involving the posterior and lateral cord at dorsal level. Significant improvement was promptly recorded with high-dose intravenous steroids, with complete recovery within one month. The strict temporal relationship between vaccination and myelitis, together with the absence of clues pointing to alternative diagnoses, might suggest a conceivable role for anti-SARS-CoV-2 vaccine as immunological trigger, although a causal relationship has yet to be established and our preliminary observation suggests caution.

Keywords: COVID-19; Myelopathy; Vaccine.

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Adult
  • COVID-19 / prevention & control*
  • COVID-19 Vaccines / administration & dosage*
  • COVID-19 Vaccines / adverse effects
  • ChAdOx1 nCoV-19
  • Female
  • Humans
  • Myelitis / chemically induced
  • Myelitis / diagnostic imaging*


  • COVID-19 Vaccines
  • ChAdOx1 nCoV-19