We report a patient with connective tissue disease who developed modest severe acute respiratory syndrome coronavirus 2 receptor binding domain-specific antibody levels and a lack of neutralization capacity, despite having received 3 mRNA coronavirus disease 2019 vaccines and holding anti-B-cell therapy for >7 months before vaccination. The patient developed virus-specific T-cell responses.
Keywords: COVID-19 vaccine; SARS-CoV-2; T-cell immunity; neutralizing antibodies; rheumatological disease.
© The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America.