Discordant Virus-Specific Antibody Levels, Antibody Neutralization Capacity, and T-cell Responses Following 3 Doses of SARS-CoV-2 Vaccination in a Patient With Connective Tissue Disease

Open Forum Infect Dis. 2021 Jul 29;8(8):ofab393. doi: 10.1093/ofid/ofab393. eCollection 2021 Aug.


We report a patient with connective tissue disease who developed modest severe acute respiratory syndrome coronavirus 2 receptor binding domain-specific antibody levels and a lack of neutralization capacity, despite having received 3 mRNA coronavirus disease 2019 vaccines and holding anti-B-cell therapy for >7 months before vaccination. The patient developed virus-specific T-cell responses.

Keywords: COVID-19 vaccine; SARS-CoV-2; T-cell immunity; neutralizing antibodies; rheumatological disease.