The role of pharmacies in haematopoietic stem cell transplantation process: A nationwide survey by Gruppo Italiano Trapianto di Midollo Osseo

J Clin Pharm Ther. 2021 Dec;46(6):1665-1679. doi: 10.1111/jcpt.13498. Epub 2021 Aug 16.


What is known and objective: The aim of this survey, conducted by the Gruppo Italiano per il Trapianto di Midollo Osseo (GITMO), was to evaluate the involvement of pharmacists in the haematopoietic stem cell transplant (HSCT) program in Italian adult and paediatric centres.

Methods: A 63-item online questionnaire was developed and sent to the Italian Transplant Programs on behalf of GITMO.

Results and discussion: Overall, 54.7% of the Italian HSCT centres participated in the survey (88.5% adult, 7.7% paediatric, 3.8% mixed), of which 50% were in public hospitals and 50% affiliated with public universities. Just over 80% declared that a pharmacist is involved in the HSCT centre, and 86.5% reported the presence of a documentation system to signal of adverse events, accessible by physicians, nurses and pharmacists in 57.7%. Chemotherapy drugs were centralized in the pharmacy in 98.1% of HSCT centres, while parenteral nutrition was centralized in 55.8%. The use of off-label drugs was authorized by an internal committee and by the regional health authorities in 88.5% of the centres. On univariate analysis, few statistically significant differences were found on response frequencies between public hospitals and university centres or between HSCT centres performing only autologous stem cell transplantation versus other centres performing autologous and allogeneic stem cell transplantation.

What is new and conclusion: This survey suggests that there is good collaboration between pharmacists and physicians and nurses in Italian HSCT transplantation centres. The enhancement of pharmacists dedicated to HSCT programs could improve some problems, for example, the centralization of parenteral nutrition.

Keywords: GITMO; haematopoietic stem cell transplantation; pharmacist; pharmacy; side effects.

MeSH terms

  • Adverse Drug Reaction Reporting Systems / organization & administration
  • Attitude of Health Personnel
  • Cooperative Behavior
  • Hematopoietic Stem Cell Transplantation*
  • Hospitals, Special / organization & administration*
  • Humans
  • Italy
  • Pharmaceutical Services / organization & administration*