Circulating Maternal sFLT1 (Soluble fms-Like Tyrosine Kinase-1) Is Sufficient to Impair Spiral Arterial Remodeling in a Preeclampsia Mouse Model

Hypertension. 2021 Sep;78(4):1067-1079. doi: 10.1161/HYPERTENSIONAHA.121.17567. Epub 2021 Aug 15.

Rebekka Vogtmann¹, Jacqueline Heupel¹, Florian Herse^{2

3}, Mahsa Matin⁴, Henning Hagmann⁴, Ivo Bendix⁵, Kristin Kräker^{2

3

6}, Ralf Dechend^{2

7}, Elke Winterhager⁸, Rainer Kimmig¹, Angela Köninger^{1

9}, Alexandra Gellhaus¹

¹ Department of Gynecology and Obstetrics, University Hospital Essen, Germany (R.V., J.H., R.K., A.K., A.G.).
² Experimental and Clinical Research Center (ECRC), a cooperation of Charité - Universitätsmedizin Berlin and Max Delbruck Center for Molecular Medicine (MDC), Berlin, Germany (F.H., K.K., R.D.).
³ Max Delbruck Center for Molecular Medicine (MDC) in the Helmholtz Association, Berlin, Germany (F.H., K.K.).
⁴ Department II of Internal Medicine-Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine-University Hospital Cologne, Cologne, Germany and Cologne Cluster of Excellence on Cellular Stress Responses in Ageing-Associated Diseases, Germany (M.M., H.H.).
⁵ Department of Pediatrics I, Neonatology & Experimental Perinatal Neurosciences, University Hospital Essen, University of Duisburg-Essen, Germany (I.B.).
⁶ Charité-Universitätsmedizin Berlin and Humboldt-Universität zu Berlin, Berlin, Germany (K.K.).
⁷ HELIOS Klinikum, Berlin, Germany (R.D.).
⁸ Imaging Center Essen, EM Unit, University Hospital Essen, Germany (E.W.).
⁹ Department of Gynecology and Obstetrics, Clinic of the Order of St. John, St. Hedwigs Clinic, Regensburg, Germany (A.K.).

Abstract

[Figure: see text].

Keywords: hypertension; mice; placenta; pregnancy; trophoblast.