Pharmacokinetics of the acyclureidopenicillins piperacillin and mezlocillin in the postpartum patient

Antimicrob Agents Chemother. 1987 Dec;31(12):2015-7. doi: 10.1128/AAC.31.12.2015.


The postpartum patient experiences numerous physiologic alterations, which may affect the pharmacokinetics of certain drugs. Six patients received either piperacillin or mezlocillin intravenously immediately after delivery. Serum half-life and clearance were, respectively, 82.4 min and 202 +/- 105 ml/min for mezlocillin and 32.9 min and 456 +/- 88 ml/min for piperacillin. The data revealed that mezlocillin and piperacillin have significantly different pharmacokinetic reactions in the postpartum patient at the doses used.

MeSH terms

  • Chromatography, High Pressure Liquid
  • Female
  • Humans
  • Methicillin / pharmacokinetics
  • Mezlocillin / pharmacokinetics*
  • Piperacillin / pharmacokinetics
  • Postpartum Period / metabolism*
  • Pregnancy


  • Mezlocillin
  • Methicillin
  • Piperacillin