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. 2021 Dec 1;181(12):1660-1662.
doi: 10.1001/jamainternmed.2021.4580.

Association of Vaccine Type and Prior SARS-CoV-2 Infection With Symptoms and Antibody Measurements Following Vaccination Among Health Care Workers

Amanda K Debes  1 , Shaoming Xiao  1 , Elizabeth Colantuoni  1 , Emily R Egbert  2 , Patrizio Caturegli  2 , Avinash Gadala  3 , Aaron M Milstone  1   2   3
Affiliations

Association of Vaccine Type and Prior SARS-CoV-2 Infection With Symptoms and Antibody Measurements Following Vaccination Among Health Care Workers

Amanda K Debes et al. JAMA Intern Med. .

Abstract

This cohort study evaluates symptoms following vaccination and antibody measurements in hospital workers who received an mRNA SARS-CoV-2 vaccine and had prior SARS-CoV-2 infection.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Milstone reported receiving grant support from Merck outside the submitted work. No other disclosures were reported.

Figures

Figure.
Figure.. Antibody Measurement More Than 14 Days Following Dose 2 of SARS-CoV-2 Messenger RNA (mRNA) Vaccines Over Time Stratified by Symptoms
Relationship of serum immunoglobulin G (IgG) antibodies recognizing the S1 subunit of spike and days after the second dose of SARS-CoV-2 mRNA vaccine in 953 hospital workers (1 participant who was receiving immunosuppressant medication did not develop IgG antibodies and is not shown). The IgG antibody measurements represent the ratio of 2 optical densities (ODs): the OD of the patient serum over the OD of an assay calibrator provided by the manufacturer. A measurement greater than 1.23 indicates the presence of spike antibodies with an upper threshold of 11 based on assay saturation., Antibody measurements were stratified by symptoms after either vaccine dose. The curves were predicted median antibody measurement over time (time was allowed as a natural cubic spline with 2 degrees of freedom) stratified by symptoms, set age, sex, vaccine type, and prior infection as the sample average. Shaded areas represent 95% CIs.
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