Luteolin and hormesis

Mech Ageing Dev. 2021 Oct;199:111559. doi: 10.1016/j.mad.2021.111559. Epub 2021 Aug 14.

Abstract

The present paper provides the first integrated assessment of the capacity of luteolin to induce hormetic dose responses. It was shown that luteolin induced hormetic responses in multiple biological systems, including enhancing neuroprotection in various experimental model disease systems, improving wounding healing, especially in experimental models of high-risk population subgroups, such as diabetics, as well as enhancing osteogenesis in models of osteoporosis. The mechanistic basis for the luteolin-induced hormetic dose responses has been demonstrated to commonly involve the upregulation of the nuclear factor erythroid-derived 2-like 2 (Nrf2), which mediates the extensive range of anti-inflammatory effects induced by luteolin in multiple cell types and organ systems.

Keywords: Anti-inflammatory; Biphasic dose response; Dose response; Hormesis; Luteolin; Neuroprotection.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Aging* / drug effects
  • Aging* / psychology
  • Animals
  • Antioxidants / metabolism
  • Antioxidants / pharmacology
  • Cellular Senescence* / drug effects
  • Cellular Senescence* / physiology
  • Disease Models, Animal
  • Flavonoids / metabolism
  • Flavonoids / pharmacology
  • Hormesis / physiology*
  • Humans
  • Luteolin* / metabolism
  • Luteolin* / pharmacology
  • NF-E2-Related Factor 2 / genetics*
  • Neuroprotective Agents / metabolism
  • Neuroprotective Agents / pharmacology
  • Osteoporosis / metabolism
  • Osteoporosis / therapy
  • Rats
  • Up-Regulation
  • Wound Healing / drug effects
  • Wound Healing / physiology

Substances

  • Antioxidants
  • Flavonoids
  • NF-E2-Related Factor 2
  • Neuroprotective Agents
  • Nfe2l2 protein, rat
  • Luteolin