Acetylcholine receptor antibodies in a patient with sensory neuropathy

Shitiz Sriwastava; Robert P Lisak

doi:10.1016/j.jneuroim.2021.577692

Acetylcholine receptor antibodies in a patient with sensory neuropathy

J Neuroimmunol. 2021 Oct 15:359:577692. doi: 10.1016/j.jneuroim.2021.577692. Epub 2021 Aug 12.

Authors

Shitiz Sriwastava¹, Robert P Lisak²

Affiliations

¹ Department of Neurology, West Virginia University, USA; Department of Neurology, Wayne State University and Detroit Medical Center, USA. Electronic address: shitiz.sriwastava@hsc.wvu.edu.
² Department of Neurology, Wayne State University and Detroit Medical Center, USA; Department of Biochemistry, Microbiology and Immunology, Wayne State University, USA.

PMID: 34403864
DOI: 10.1016/j.jneuroim.2021.577692

Abstract

Antibodies to acetylcholine receptor (AChR) are detected in the vast majority of patients with generalized myasthenia gravis (MG) and are rarely detected in significant titer in other autoimmune diseases. We report a patient with an axonal predominately sensory neuropathy for over 12 years with persistent binding and modulating AChR antibodies as well as striational muscle antibodies with no evidence of MG or any neoplastic disease.

Keywords: Acetylcholine receptor antibodies; Autoimmune disorder; Myasthenia gravis; Sensory neuropathy.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Autoantibodies / blood*
Autoantibodies / immunology
Humans
Male
Myasthenia Gravis / blood
Myasthenia Gravis / diagnosis
Myasthenia Gravis / immunology
Peripheral Nervous System Diseases / blood*
Peripheral Nervous System Diseases / diagnosis
Peripheral Nervous System Diseases / immunology
Receptors, Cholinergic / biosynthesis*
Receptors, Cholinergic / immunology

Substances

Autoantibodies
Receptors, Cholinergic