Acetylcholine receptor antibodies in a patient with sensory neuropathy

J Neuroimmunol. 2021 Oct 15;359:577692. doi: 10.1016/j.jneuroim.2021.577692. Epub 2021 Aug 12.

Abstract

Antibodies to acetylcholine receptor (AChR) are detected in the vast majority of patients with generalized myasthenia gravis (MG) and are rarely detected in significant titer in other autoimmune diseases. We report a patient with an axonal predominately sensory neuropathy for over 12 years with persistent binding and modulating AChR antibodies as well as striational muscle antibodies with no evidence of MG or any neoplastic disease.

Keywords: Acetylcholine receptor antibodies; Autoimmune disorder; Myasthenia gravis; Sensory neuropathy.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Autoantibodies / blood*
  • Autoantibodies / immunology
  • Humans
  • Male
  • Myasthenia Gravis / blood
  • Myasthenia Gravis / diagnosis
  • Myasthenia Gravis / immunology
  • Peripheral Nervous System Diseases / blood*
  • Peripheral Nervous System Diseases / diagnosis
  • Peripheral Nervous System Diseases / immunology
  • Receptors, Cholinergic / biosynthesis*
  • Receptors, Cholinergic / immunology

Substances

  • Autoantibodies
  • Receptors, Cholinergic