Primary Graft Dysfunction after Heart Transplantation - Unravelling the Enigma

Ahmed Al-Adhami; Sanjeet Singh Avtaar Singh; Sudeep Das De; Ramesh Singh; Gurusher Panjrath; Amit Shah; Jonathan R Dalzell; Jacob Schroder; Nawwar Al-Attar

doi:10.1016/j.cpcardiol.2021.100941

Primary Graft Dysfunction after Heart Transplantation - Unravelling the Enigma

Curr Probl Cardiol. 2022 Aug;47(8):100941. doi: 10.1016/j.cpcardiol.2021.100941. Epub 2021 Jul 24.

Authors

Ahmed Al-Adhami¹, Sanjeet Singh Avtaar Singh², Sudeep Das De³, Ramesh Singh⁴, Gurusher Panjrath⁵, Amit Shah⁶, Jonathan R Dalzell⁷, Jacob Schroder⁸, Nawwar Al-Attar⁹

Affiliations

¹ Department of Cardiothoracic Surgery, Golden Jubilee National Hospital, Glasgow UK.
² Department of Cardiothoracic Surgery, Golden Jubilee National Hospital, Glasgow UK; Institute of Cardiovascular and Medical Sciences (ICAMS), University of Glasgow. Electronic address: sanjeet.singh@glasgow.ac.uk.
³ Department of Cardiothoracic Surgery, Royal Infirmary of Edinburgh, Edinburgh, UK.
⁴ Mechanical Circulatory Support, Inova Health System, Falls Church, Virginia.
⁵ Heart Failure and Mechanical Circulatory Support Program, George Washington University Hospital, Washington, DC.
⁶ Advanced Heart Failure and Cardiac Transplant Unit, Fiona Stanley Hospital, Perth, Australia.
⁷ Scottish National Advanced Heart Failure Service, Golden Jubilee National Hospital, Glasgow, UK.
⁸ Heart Transplantation Program, Division of Cardiovascular and Thoracic Surgery, Duke University Medical Center, Durham, NC.
⁹ Department of Cardiothoracic Surgery, Golden Jubilee National Hospital, Glasgow UK; Institute of Cardiovascular and Medical Sciences (ICAMS), University of Glasgow.

PMID: 34404551
DOI: 10.1016/j.cpcardiol.2021.100941

Abstract

Primary graft dysfunction (PGD) remains the main cause of early mortality following heart transplantation despite several advances in donor preservation techniques and therapeutic strategies for PGD. With that aim of establishing the aetiopathogenesis of PGD and the preferred management strategies, the new consensus definition has paved the way for multiple contemporaneous studies to be undertaken and accurately compared. This review aims to provide a broad-based understanding of the pathophysiology, clinical presentation and management of PGD.

Publication types

Review

MeSH terms

Heart Transplantation* / adverse effects
Humans
Primary Graft Dysfunction* / etiology
Primary Graft Dysfunction* / therapy
Risk Factors