Primary Graft Dysfunction after Heart Transplantation - Unravelling the Enigma

Curr Probl Cardiol. 2022 Aug;47(8):100941. doi: 10.1016/j.cpcardiol.2021.100941. Epub 2021 Jul 24.


Primary graft dysfunction (PGD) remains the main cause of early mortality following heart transplantation despite several advances in donor preservation techniques and therapeutic strategies for PGD. With that aim of establishing the aetiopathogenesis of PGD and the preferred management strategies, the new consensus definition has paved the way for multiple contemporaneous studies to be undertaken and accurately compared. This review aims to provide a broad-based understanding of the pathophysiology, clinical presentation and management of PGD.

Publication types

  • Review

MeSH terms

  • Heart Transplantation* / adverse effects
  • Humans
  • Primary Graft Dysfunction* / etiology
  • Primary Graft Dysfunction* / therapy
  • Risk Factors