Breast implant seroma: A SARS-CoV-2 mRNA vaccine side effect

J Clin Ultrasound. 2021 Nov;49(9):984-986. doi: 10.1002/jcu.23056. Epub 2021 Aug 18.


Fluid collection surrounding breast implants, called seroma, is a frequent issue that has diverse etiologies. We describe a 48-year-old woman with an acute onset of bilateral breast swelling occurring 5 years after aesthetic surgery and 10 days after a second SARS-CoV-2 mRNA vaccine dose. At breast ultrasound, we found an abundant bilateral peri-implant seroma. Our patient noticed symptom improvement 48 h after nonsteroidal anti-inflammatory drug treatment, complete disappearance of symptoms after 10 days with seroma disappearance documented by ultrasound. We hypothesized a breast implant seroma as post-SARS-CoV-2 mRNA vaccine side effect, as different other diagnosis had been excluded.

Keywords: COVID; breast implants; seroma; ultrasound; vaccine.

Publication types

  • Case Reports

MeSH terms

  • Breast Implants* / adverse effects
  • COVID-19 Vaccines
  • COVID-19*
  • Female
  • Humans
  • Middle Aged
  • RNA, Messenger
  • SARS-CoV-2
  • Seroma / diagnostic imaging
  • Seroma / etiology


  • COVID-19 Vaccines
  • RNA, Messenger