Cognitive functioning in everyday life: The development of a questionnaire on instrumental activities of daily living in multiple sclerosis

Mult Scler J Exp Transl Clin. 2021 Aug 3;7(3):20552173211038027. doi: 10.1177/20552173211038027. eCollection 2021 Jul-Sep.


Neuropsychological test scores in people with MS (PwMS) do not fully reflect cognitive functioning in daily life. Therefore, we developed a questionnaire based on instrumental activities of daily living (IADL), using the Amsterdam IADL-Q© for Alzheimer's disease as starting point. Forty-eight items were evaluated on relevance and clarity by (inter)national experts (n = 30), PwMS (n = 61) and proxies (n = 30). Consequently, four items were omitted, two items were merged and seven items were added. Fifty items were included in the IADL questionnaire specific to cognitive functioning in MS (the MS-IADL-Q). Future studies are warranted to assess the psychometric properties of the MS-IADL-Q.

Keywords: Amsterdam IADL Questionnaire; MS-IADL-Q; Multiple sclerosis; cognition; instrumental activities of daily living.