Influence of N,N'-(1,11-undecandiyl) bis (2,3-dihydro-2-methyl-1H-indole-1-carboxamide) (BAY 02752) on gallstone formation and regression in hamsters

Pharmacol Res Commun. 1987 Oct;19(10):679-84. doi: 10.1016/0031-6989(87)90098-1.

Abstract

A new hypolipidemic drug (BAY 02752) when added to a lithogenic hamster diet at dosages of 1000 and 500 mg per kg of diet significantly (p less than 0.005) inhibited gallstone formation. When BAY 02752 was fed to hamsters with pre-established gallstones, it inhibited progression (p=0.052) of the stones and appeared to promote dissolution.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cholelithiasis / drug therapy
  • Cholelithiasis / prevention & control*
  • Cricetinae
  • Diet
  • Hypolipidemic Agents / therapeutic use*
  • Indoles / therapeutic use*
  • Male
  • Mesocricetus

Substances

  • Hypolipidemic Agents
  • Indoles
  • Bay 02752