Reports of anaphylaxis after coronavirus disease 2019 vaccination, South Korea, 26 February to 30 April 2021

Euro Surveill. 2021 Aug;26(33):2100694. doi: 10.2807/1560-7917.ES.2021.26.33.2100694.


The South Korea mass vaccination programme administered 3.8 million doses of COVID-19 vaccinations between 26 February and 30 April 2021. After 173 suspected anaphylaxis reports to the nationwide monitoring system for adverse events following immunisation, 44 anaphylaxis cases were confirmed using Brighton Collaboration case definitions. The rates per million doses were 18.2 cases and 6.2 cases for Vaxzevria and Comirnaty, respectively. Median time of onset was 14 min after vaccination and most cases had recovered at the time of review.

Keywords: Brighton Collaboration case definition; COVID-19 vaccination; adverse events; anaphylaxis.

MeSH terms

  • Anaphylaxis* / chemically induced
  • Anaphylaxis* / diagnosis
  • Anaphylaxis* / epidemiology
  • COVID-19*
  • Humans
  • Mass Vaccination
  • Republic of Korea / epidemiology
  • SARS-CoV-2
  • Vaccination / adverse effects