m7G tRNA modification reveals new secrets in the translational regulation of cancer development

Olga Katsara; Robert J Schneider

doi:10.1016/j.molcel.2021.07.030

m⁷G tRNA modification reveals new secrets in the translational regulation of cancer development

Mol Cell. 2021 Aug 19;81(16):3243-3245. doi: 10.1016/j.molcel.2021.07.030.

Authors

Olga Katsara¹, Robert J Schneider²

Affiliations

¹ Department of Microbiology, NYU Grossman School of Medicine, New York, NY 10016, USA.
² Department of Microbiology, NYU Grossman School of Medicine, New York, NY 10016, USA. Electronic address: robert.schneider@nyulangone.org.

PMID: 34416137
DOI: 10.1016/j.molcel.2021.07.030

Abstract

Orellana et al. (2021) and Dai et al. (2021) demonstrate that increased m⁷G modification of a subset of tRNAs by the METTL1/WDR4 complex stabilizes these mRNAs against decay, increases translation efficiency, reduces ribosome pausing, is associated with poor survival in human cancers, and is directly transforming.

Publication types

Comment

MeSH terms

GTP-Binding Proteins / metabolism
Humans
Neoplasms* / genetics
Neoplasms* / metabolism
RNA Processing, Post-Transcriptional*
RNA, Messenger / genetics
RNA, Messenger / metabolism
RNA, Transfer / genetics
RNA, Transfer / metabolism
Ribosomes / genetics
Ribosomes / metabolism

Substances

RNA, Messenger
WDR4 protein, human
RNA, Transfer
GTP-Binding Proteins