m7G tRNA modification reveals new secrets in the translational regulation of cancer development

Mol Cell. 2021 Aug 19;81(16):3243-3245. doi: 10.1016/j.molcel.2021.07.030.

Abstract

Orellana et al. (2021) and Dai et al. (2021) demonstrate that increased m7G modification of a subset of tRNAs by the METTL1/WDR4 complex stabilizes these mRNAs against decay, increases translation efficiency, reduces ribosome pausing, is associated with poor survival in human cancers, and is directly transforming.

Publication types

  • Comment

MeSH terms

  • GTP-Binding Proteins / metabolism
  • Humans
  • Neoplasms* / genetics
  • Neoplasms* / metabolism
  • RNA Processing, Post-Transcriptional*
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • RNA, Transfer / genetics
  • RNA, Transfer / metabolism
  • Ribosomes / genetics
  • Ribosomes / metabolism

Substances

  • RNA, Messenger
  • WDR4 protein, human
  • RNA, Transfer
  • GTP-Binding Proteins