Fulminant myocarditis and systemic hyperinflammation temporally associated with BNT162b2 mRNA COVID-19 vaccination in two patients

Int J Cardiol. 2021 Oct 1;340:119-121. doi: 10.1016/j.ijcard.2021.08.018. Epub 2021 Aug 18.


Immune-mediated myocardial injury following Severe Acute Respiratory Syndrome Coronavirys-2 (SARS-CoV2) infection has been described in adults and children. Cases of myocarditis following immunization for SARS-CoV2 have recently been documented, mostly associated with mild severity and spontaneous recovery. We herein report two cases of fulminant myocarditis following BNT162b2 mRNA Covid-19 vaccination associated with systemic hyperinflammatory syndrome and refractory shock requiring support with veno-arterial extracorporeal membrane oxygenation.

Keywords: Coronavirus; Covid-19; Myocarditis; Vaccine.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • BNT162 Vaccine
  • COVID-19 Vaccines
  • COVID-19*
  • Child
  • Humans
  • Myocarditis* / diagnosis
  • RNA, Messenger
  • RNA, Viral
  • SARS-CoV-2
  • Systemic Inflammatory Response Syndrome
  • Vaccination / adverse effects


  • COVID-19 Vaccines
  • RNA, Messenger
  • RNA, Viral
  • BNT162 Vaccine

Supplementary concepts

  • pediatric multisystem inflammatory disease, COVID-19 related