6β-Hydroxytestosterone Promotes Angiotensin II-Induced Hypertension via Enhanced Cytosolic Phospholipase A₂α Activity

Hypertension. 2021 Sep;78(4):1053-1066. doi: 10.1161/HYPERTENSIONAHA.121.17927. Epub 2021 Aug 23.

Authors

Purnima Singh¹, Chi Young Song¹, Shubha R Dutta¹, Ajeeth Pingili¹, Ji Soo Shin¹, Frank J Gonzalez², Joseph V Bonventre³, Kafait U Malik¹

Affiliations

¹ Department of Pharmacology, Addiction Research, and Toxicology, College of Medicine, University of Tennessee Health Science Center, Memphis (P.S., C.Y.S., S.R.D., A.P., J.S.S., K.U.M.).
² Laboratory of Metabolism, National Cancer Institute, Bethesda, MD (F.J.G.).
³ Renal Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Harvard Institute of Medicine, Boston, MA (J.V.B.).

Abstract

[Figure: see text].

Keywords: blood pressure; hypertension; mice; tail; testosterone.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Angiotensin II / pharmacology*
Animals
Cytochrome P-450 CYP1B1 / physiology
Cytokines / metabolism
Dinoprostone / physiology
Group IV Phospholipases A2 / metabolism*
Hydroxytestosterones / pharmacology*
Hypertension / chemically induced*
Mice
Mice, Inbred C57BL
Reactive Oxygen Species / metabolism
Thromboxane A2 / physiology

Substances

Cytokines
Hydroxytestosterones
Reactive Oxygen Species
Angiotensin II
Thromboxane A2
6 beta-hydroxytestosterone
Cyp1b1 protein, mouse
Cytochrome P-450 CYP1B1
Group IV Phospholipases A2
Dinoprostone

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