Recent Developments About the Pathogenesis of Dry Eye Disease: Based on Immune Inflammatory Mechanisms

Lifei Yu; Chunjing Yu; He Dong; Yanan Mu; Rui Zhang; Qiaosi Zhang; Wei Liang; Wenjia Li; Xun Wang; Lijun Zhang

doi:10.3389/fphar.2021.732887

Recent Developments About the Pathogenesis of Dry Eye Disease: Based on Immune Inflammatory Mechanisms

Front Pharmacol. 2021 Aug 5:12:732887. doi: 10.3389/fphar.2021.732887. eCollection 2021.

Authors

Lifei Yu¹, Chunjing Yu¹, He Dong¹, Yanan Mu¹, Rui Zhang¹, Qiaosi Zhang¹, Wei Liang¹, Wenjia Li¹, Xun Wang², Lijun Zhang¹

Affiliations

¹ Department of Ophthalmology, The Third People's Hospital of Dalian, Non-Directly Affiliated Hospital of Dalian Medical University, Dalian, China.
² Department of Neurosurgery, The Third People's Hospital of Dalian, Non-Directly Affiliated Hospital of Dalian Medical University, Dalian, China.

Abstract

Dry eye disease is a common and frequently occurring ophthalmology with complex and diverse causes, and its incidence is on the upward trend. The pathogenesis of DED is still completely clear. However, the immune response based on inflammation has been recognized as the core basis of this disease. In this review, we will systematically review the previous research on the treatment of DED in immune inflammation, analyze the latest views and research hotspots, and provide reference for the prevention and treatment of DED.

Keywords: Dry eye disease; immunity; inflammation; pharmaceuticals; treatment.

Publication types

Review