Novel assessment of leukocyte-rich platelet-rich plasma on functional and patient-reported outcomes in knee osteoarthritis: a pilot study

Regen Med. 2021 Sep;16(9):823-832. doi: 10.2217/rme-2021-0032. Epub 2021 Aug 23.


Background: Leukocyte-rich platelet-rich plasma (LR-PRP) has demonstrated to be beneficial for patients with knee osteoarthritis (KOA); however, reliable objective end points to accurately assess its therapeutic effects is lacking. Aim: To investigate the efficacy of LR-PRP as assessed by functional and patient-reported outcomes at early time points (6 weeks). Materials & methods: We conducted a prospective cohort study in 12 patients with diagnosed KOA (Kellgren Lawrence score of II-III), who underwent a single ultrasound-guided LR-PRP injection. Results: There was significant improvement in timed up and go, pain and quality of life scales and balance parameters. There were nonsignificant improvements in range of motion and gait parameters. Conclusion: LR-PRP demonstrates efficacy in meaningful end points for functional and patient-reported outcomes at early time points in patients with KOA.

Keywords: balance; functional outcomes; gait; knee injury and osteoarthritis outcome score 12; knee osteoarthritis; leukocyte-rich platelet-rich plasma; patient-reported outcomes; timed up and go; wearable sensor technology.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Humans
  • Hyaluronic Acid
  • Injections, Intra-Articular
  • Leukocytes
  • Osteoarthritis, Knee* / diagnostic imaging
  • Osteoarthritis, Knee* / therapy
  • Patient Reported Outcome Measures
  • Pilot Projects
  • Platelet-Rich Plasma*
  • Prospective Studies
  • Quality of Life
  • Treatment Outcome


  • Hyaluronic Acid