Molecular mechanisms and applications of tea polyphenols: A narrative review

doi:10.1111/jfbc.13910

Review

. 2021 Oct;45(10):e13910.

doi: 10.1111/jfbc.13910. Epub 2021 Aug 23.

Molecular mechanisms and applications of tea polyphenols: A narrative review

Yan Chen^{1

2

3}, Si Cheng², Jiangang Dai², Liang Wang², Yun Xu², Xiaoyu Peng², Xiaofang Xie^{1

3}, Cheng Peng^{1

3}

Affiliations

¹ State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu, China.
² School of Public Health, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
³ College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

PMID: 34426979
DOI: 10.1111/jfbc.13910

Review

Molecular mechanisms and applications of tea polyphenols: A narrative review

Yan Chen et al. J Food Biochem. 2021 Oct.

. 2021 Oct;45(10):e13910.

doi: 10.1111/jfbc.13910. Epub 2021 Aug 23.

Authors

Yan Chen^{1

2

3}, Si Cheng², Jiangang Dai², Liang Wang², Yun Xu², Xiaoyu Peng², Xiaofang Xie^{1

3}, Cheng Peng^{1

3}

Affiliations

¹ State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu, China.
² School of Public Health, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
³ College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

PMID: 34426979
DOI: 10.1111/jfbc.13910

Abstract

Tea is a worldwide popular drink with high nutritional and medicinal values as it is rich in nutrients, such as polyphenols, amino acids, vitamins, glycosides, and so on. Among them, tea polyphenols (TPs) are the current research hotspot. TPs are known to have multiple biological activities such as anti-oxidation, anti-tumor, anti-inflammation, anti-bacteria, lowering lipid, and liver protection. By reviewing a large number of literatures, we explained the mechanism of TPs exerting biological activity and a wide range of applications. We also discussed the deficiencies and development potential of TPs, in order to provide theoretical reference and scientific basis for the subsequent development and utilization of TPs. PRACTICAL APPLICATIONS: We summarized the bioactivity mechanisms of TPs in anti-tumor, anti-oxidation, antibacterial, anti-inflammatory, lipid-lowering, and liver protection, focused on its application fields in food and medicine, and discussed the deficiency and development potential of current research on TPs, so as to provide a certain convenient way for scholars studying TPs. It is expected to contribute to the subsequent discovery of biological activity and the broadening of the field of TPs.

Keywords: biological activity; development; tea polyphenols; utilization.

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References

REFERENCES

1. Anand, P. K., Kaul, D., & Sharma, M. (2006). Green tea polyphenol inhibits Mycobacterium tuberculosis survival within human macrophages. The International Journal of Biochemistry & Cell Biology, 38, 600-609. https://doi.org/10.1016/j.biocel.2005.10.021
1. Bai, G. Q., Ma, S. H., Qie, R. T., Liu, Z. Q., Shi, Y. L., Li, C. H., Wang, R. J., Guo, X. H., Zhou, F., & Jia, X. (2016). UV-triggered surface-initiated polymerization from colorless green tea polyphenol-coated surfaces. Macromolecular Rapid Communications, 37. https://doi.org/10.1002/marc.201600065
1. Ben Lagha, A., Haas, B., & Grenier, D. (2017). Tea polyphenols inhibit the growth and virulence properties of Fusobacterium nucleatum. Scientific Reports, 7, 44815. https://doi.org/10.1038/srep44815
1. Bettaieb, A., Vazquez Prieto, M. A., Lanzi, C. R., Miatello, R. M., Haj, F. G., Fraga, C. G., & Oteiza, P. I. (2014). (−)-Epicatechin mitigates high-fructose-associated insulin resistance by modulating redox signaling and endoplasmic reticulum stress. Free Radical Biology and Medicine, 72, 247-256. https://doi.org/10.1016/j.freeradbiomed.2014.04.011
1. Bimonte, S., Cascella, M., Barbieri, A., Arra, C., & Cuomo, A. (2020). Current shreds of evidence on the anticancer role of EGCG in triple negative breast cancer: An update of the current state of knowledge. Infectious Agents and Cancer, 15, 2. https://doi.org/10.1186/s13027-020-0270-5

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[1] Anand, P. K., Kaul, D., & Sharma, M. (2006). Green tea polyphenol inhibits Mycobacterium tuberculosis survival within human macrophages. The International Journal of Biochemistry & Cell Biology, 38, 600-609. https://doi.org/10.1016/j.biocel.2005.10.021

[2] Anand, P. K., Kaul, D., & Sharma, M. (2006). Green tea polyphenol inhibits Mycobacterium tuberculosis survival within human macrophages. The International Journal of Biochemistry & Cell Biology, 38, 600-609. https://doi.org/10.1016/j.biocel.2005.10.021

[3] Bai, G. Q., Ma, S. H., Qie, R. T., Liu, Z. Q., Shi, Y. L., Li, C. H., Wang, R. J., Guo, X. H., Zhou, F., & Jia, X. (2016). UV-triggered surface-initiated polymerization from colorless green tea polyphenol-coated surfaces. Macromolecular Rapid Communications, 37. https://doi.org/10.1002/marc.201600065

[4] Bai, G. Q., Ma, S. H., Qie, R. T., Liu, Z. Q., Shi, Y. L., Li, C. H., Wang, R. J., Guo, X. H., Zhou, F., & Jia, X. (2016). UV-triggered surface-initiated polymerization from colorless green tea polyphenol-coated surfaces. Macromolecular Rapid Communications, 37. https://doi.org/10.1002/marc.201600065

[5] Ben Lagha, A., Haas, B., & Grenier, D. (2017). Tea polyphenols inhibit the growth and virulence properties of Fusobacterium nucleatum. Scientific Reports, 7, 44815. https://doi.org/10.1038/srep44815

[6] Ben Lagha, A., Haas, B., & Grenier, D. (2017). Tea polyphenols inhibit the growth and virulence properties of Fusobacterium nucleatum. Scientific Reports, 7, 44815. https://doi.org/10.1038/srep44815

[7] Bettaieb, A., Vazquez Prieto, M. A., Lanzi, C. R., Miatello, R. M., Haj, F. G., Fraga, C. G., & Oteiza, P. I. (2014). (−)-Epicatechin mitigates high-fructose-associated insulin resistance by modulating redox signaling and endoplasmic reticulum stress. Free Radical Biology and Medicine, 72, 247-256. https://doi.org/10.1016/j.freeradbiomed.2014.04.011

[8] Bettaieb, A., Vazquez Prieto, M. A., Lanzi, C. R., Miatello, R. M., Haj, F. G., Fraga, C. G., & Oteiza, P. I. (2014). (−)-Epicatechin mitigates high-fructose-associated insulin resistance by modulating redox signaling and endoplasmic reticulum stress. Free Radical Biology and Medicine, 72, 247-256. https://doi.org/10.1016/j.freeradbiomed.2014.04.011

[9] Bimonte, S., Cascella, M., Barbieri, A., Arra, C., & Cuomo, A. (2020). Current shreds of evidence on the anticancer role of EGCG in triple negative breast cancer: An update of the current state of knowledge. Infectious Agents and Cancer, 15, 2. https://doi.org/10.1186/s13027-020-0270-5

[10] Bimonte, S., Cascella, M., Barbieri, A., Arra, C., & Cuomo, A. (2020). Current shreds of evidence on the anticancer role of EGCG in triple negative breast cancer: An update of the current state of knowledge. Infectious Agents and Cancer, 15, 2. https://doi.org/10.1186/s13027-020-0270-5

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Molecular mechanisms and applications of tea polyphenols: A narrative review

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Molecular mechanisms and applications of tea polyphenols: A narrative review

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Abstract

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