Who watches the watchmen? RNAi pathway-derived ribosomal small RNAs burgeon in absence of piRNAs

Navin B Ramakrishna; Eric A Miska

doi:10.1016/j.devcel.2021.08.002

Who watches the watchmen? RNAi pathway-derived ribosomal small RNAs burgeon in absence of piRNAs

Dev Cell. 2021 Aug 23;56(16):2269-2270. doi: 10.1016/j.devcel.2021.08.002.

Authors

Navin B Ramakrishna¹, Eric A Miska²

Affiliations

¹ Wellcome/CRUK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge, UK; Department of Genetics, University of Cambridge, Downing Street, Cambridge, UK.
² Wellcome/CRUK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge, UK; Department of Genetics, University of Cambridge, Downing Street, Cambridge, UK; Wellcome Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK. Electronic address: eam29@cam.ac.uk.

PMID: 34428395
DOI: 10.1016/j.devcel.2021.08.002

Abstract

Instead of causing immediate sterility, loss of the C. elegans PIWI protein PRG-1 leads to accumulated infertility after tens of generations. In this issue of Developmental Cell, Wahba et al. show that this correlates with aberrant RNA interference pathway-dependent feed forward amplification of ribosomal siRNAs-the proposed accumulative sterility factor.

Publication types

Comment

MeSH terms

Animals
Argonaute Proteins / genetics
Argonaute Proteins / metabolism
Caenorhabditis elegans Proteins* / genetics
Caenorhabditis elegans Proteins* / metabolism
Caenorhabditis elegans* / genetics
Caenorhabditis elegans* / metabolism
RNA Interference
RNA, Ribosomal
RNA, Small Interfering / genetics

Substances

Argonaute Proteins
Caenorhabditis elegans Proteins
PRG-1 protein, C elegans
RNA, Ribosomal
RNA, Small Interfering