Physical activity and cognitive and imaging biomarkers of Alzheimer's disease in down syndrome

doi:10.1016/j.neurobiolaging.2021.07.016

. 2021 Nov:107:118-127.

doi: 10.1016/j.neurobiolaging.2021.07.016. Epub 2021 Jul 29.

Physical activity and cognitive and imaging biomarkers of Alzheimer's disease in down syndrome

Affiliations

¹ Waisman Center, University of Wisconsin-Madison, Madison, WI, USA; School of Human Ecology, University of Wisconsin-Madison, Madison, WI, USA.
² Waisman Center, University of Wisconsin-Madison, Madison, WI, USA; Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, USA.
³ Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
⁴ Department of Radiology, University of Pittsburgh, Pittsburgh, PA, USA.
⁵ Department of Neurology, Washington University at St. Louis, St. Louis, MO, USA.
⁶ Department of Psychiatry, University of Wisconsin-Madison, Madison, WI, USA.
⁷ Department of Psychiatry, University of Wisconsin-Madison, Madison, WI, USA; Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.
⁸ Waisman Center, University of Wisconsin-Madison, Madison, WI, USA; School of Human Ecology, University of Wisconsin-Madison, Madison, WI, USA. Electronic address: slhartley@wisc.edu.

PMID: 34428720
PMCID: PMC8641014
DOI: 10.1016/j.neurobiolaging.2021.07.016

Free PMC article

Physical activity and cognitive and imaging biomarkers of Alzheimer's disease in down syndrome

Victoria Fleming et al. Neurobiol Aging. 2021 Nov.

Free PMC article

. 2021 Nov:107:118-127.

doi: 10.1016/j.neurobiolaging.2021.07.016. Epub 2021 Jul 29.

Affiliations

¹ Waisman Center, University of Wisconsin-Madison, Madison, WI, USA; School of Human Ecology, University of Wisconsin-Madison, Madison, WI, USA.
² Waisman Center, University of Wisconsin-Madison, Madison, WI, USA; Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, USA.
³ Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
⁴ Department of Radiology, University of Pittsburgh, Pittsburgh, PA, USA.
⁵ Department of Neurology, Washington University at St. Louis, St. Louis, MO, USA.
⁶ Department of Psychiatry, University of Wisconsin-Madison, Madison, WI, USA.
⁷ Department of Psychiatry, University of Wisconsin-Madison, Madison, WI, USA; Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.
⁸ Waisman Center, University of Wisconsin-Madison, Madison, WI, USA; School of Human Ecology, University of Wisconsin-Madison, Madison, WI, USA. Electronic address: slhartley@wisc.edu.

PMID: 34428720
PMCID: PMC8641014
DOI: 10.1016/j.neurobiolaging.2021.07.016

Abstract

Adults with Down syndrome (DS) are at risk for Alzheimer's disease. Despite sharing trisomy 21, however, there is variability in the age of disease onset. This variability may mean that other factors, such as lifestyle, influence cognitive aging and disease timing. The present study assessed the association between everyday life physical activity using an actigraph accelerometer and cognitive functioning and early Alzheimer's disease pathology via positron emission tomography amyloid-β and tau and diffusion tension imaging measures of white matter integrity in 61 non-demented adults with DS. Percent time in sedentary behavior and in moderate-to-vigorous activity were associated (negatively and positively, respectively) with cognitive functioning (r = -.472 to .572, p < 0.05). Neither sedentary behavior nor moderate-to-vigorous activity were associated with amyloid-β or tau, but both were associated with white matter integrity in the superior and inferior longitudinal fasciculus (Fractional Anisotropy: r = -.397 to -.419, p < 0.05; Mean Diffusivity: r = .400, p < 0.05). Longitudinal studies are needed to determine if physical activity promotes healthy aging in DS.

Keywords: Alzheimer's disease; Biomarkers; Cognitive functioning; Down syndrome; Physical activity.

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References

1. Ball S, Holland A, Treppner P, Watson P, & Huppert F. Executive dysfunction and its association with personality and behaviour changes in the development of Alzheimer’s disease in adults with Down syndrome and mild to moderate learning disabilities. Brit J Clin Psychol. 2008; 47, 1–29. - PubMed
1. Beery K, Buktencia N, Beery N 2004. The Beery-Buktencia developmental test of visual-motor intetration. 5th edn. Bloomington, MN: Pearson
1. Blodgett J, Theou O, Kirkland S, Andreou P, Rockwood K, 2015. The association between sedentary behaviour, moderate-vigorousphysical activity and frailty in NHANES cohorts. Maturitas 80, 187–191. 10.1016/j.maturitas.2014.11.010 - DOI - PubMed
1. Bosch B, Arenaza-Urquijo EM, Rami L, Sala-Llonch R, Junqué C, Solé-Padullés C, Peña-Gómez C, Bargalló N, Molinuevo JL, Bartrés-Faz D, 2012. Multiple DTI index analysis in normal aging, amnestic MCI and AD. Relationship with neuropsychological performance. Neurobiol. Aging 33, 61–74. 10.1016/j.neurobiolaging.2010.02.004 - DOI - PubMed
1. Braak H, Alafuzoff I, Arzberger T, Kretzschmar H, Tredici K, 2006. Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry. Acta Neuropathol. 112, 389–404. 10.1007/s00401-006-0127-z - DOI - PMC - PubMed

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[1] Ball S, Holland A, Treppner P, Watson P, & Huppert F. Executive dysfunction and its association with personality and behaviour changes in the development of Alzheimer’s disease in adults with Down syndrome and mild to moderate learning disabilities. Brit J Clin Psychol. 2008; 47, 1–29. - PubMed

[2] Ball S, Holland A, Treppner P, Watson P, & Huppert F. Executive dysfunction and its association with personality and behaviour changes in the development of Alzheimer’s disease in adults with Down syndrome and mild to moderate learning disabilities. Brit J Clin Psychol. 2008; 47, 1–29. - PubMed

[3] Beery K, Buktencia N, Beery N 2004. The Beery-Buktencia developmental test of visual-motor intetration. 5th edn. Bloomington, MN: Pearson

[4] Beery K, Buktencia N, Beery N 2004. The Beery-Buktencia developmental test of visual-motor intetration. 5th edn. Bloomington, MN: Pearson

[5] Blodgett J, Theou O, Kirkland S, Andreou P, Rockwood K, 2015. The association between sedentary behaviour, moderate-vigorousphysical activity and frailty in NHANES cohorts. Maturitas 80, 187–191. 10.1016/j.maturitas.2014.11.010 - DOI - PubMed

[6] Blodgett J, Theou O, Kirkland S, Andreou P, Rockwood K, 2015. The association between sedentary behaviour, moderate-vigorousphysical activity and frailty in NHANES cohorts. Maturitas 80, 187–191. 10.1016/j.maturitas.2014.11.010 - DOI - PubMed

[7] Bosch B, Arenaza-Urquijo EM, Rami L, Sala-Llonch R, Junqué C, Solé-Padullés C, Peña-Gómez C, Bargalló N, Molinuevo JL, Bartrés-Faz D, 2012. Multiple DTI index analysis in normal aging, amnestic MCI and AD. Relationship with neuropsychological performance. Neurobiol. Aging 33, 61–74. 10.1016/j.neurobiolaging.2010.02.004 - DOI - PubMed

[8] Bosch B, Arenaza-Urquijo EM, Rami L, Sala-Llonch R, Junqué C, Solé-Padullés C, Peña-Gómez C, Bargalló N, Molinuevo JL, Bartrés-Faz D, 2012. Multiple DTI index analysis in normal aging, amnestic MCI and AD. Relationship with neuropsychological performance. Neurobiol. Aging 33, 61–74. 10.1016/j.neurobiolaging.2010.02.004 - DOI - PubMed

[9] Braak H, Alafuzoff I, Arzberger T, Kretzschmar H, Tredici K, 2006. Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry. Acta Neuropathol. 112, 389–404. 10.1007/s00401-006-0127-z - DOI - PMC - PubMed

[10] Braak H, Alafuzoff I, Arzberger T, Kretzschmar H, Tredici K, 2006. Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry. Acta Neuropathol. 112, 389–404. 10.1007/s00401-006-0127-z - DOI - PMC - PubMed

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Physical activity and cognitive and imaging biomarkers of Alzheimer's disease in down syndrome

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Physical activity and cognitive and imaging biomarkers of Alzheimer's disease in down syndrome

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