Altered stress granule disassembly: links to neurodegenerative disease?

Alicia Dubinski; Christine Vande Velde

doi:10.1016/j.tins.2021.08.001

Altered stress granule disassembly: links to neurodegenerative disease?

Trends Neurosci. 2021 Oct;44(10):765-766. doi: 10.1016/j.tins.2021.08.001. Epub 2021 Aug 21.

Authors

Alicia Dubinski¹, Christine Vande Velde²

Affiliations

¹ Department of Neurosciences, Université de Montréal & Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada.
² Department of Neurosciences, Université de Montréal & Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada. Electronic address: c.vande.velde@umontreal.ca.

PMID: 34429216
DOI: 10.1016/j.tins.2021.08.001

Abstract

A recent study by Gwon et al. identified context-specific ubiquitination of G3BP1 as critical for stress granule disassembly via VCP and the adaptor FAF2. This study provides new insights into stress granule dynamics, with potential implications for neurodegenerative disease.

Keywords: G3BP1; RNA granules; amyotrophic lateral sclerosis; frontotemporal dementia; neurodegeneration; pathomechanism.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amyotrophic Lateral Sclerosis*
DNA Helicases / metabolism
Humans
Neurodegenerative Diseases*
Poly-ADP-Ribose Binding Proteins
RNA Helicases / metabolism
RNA Recognition Motif Proteins

Substances

Poly-ADP-Ribose Binding Proteins
RNA Recognition Motif Proteins
DNA Helicases
G3BP1 protein, human
RNA Helicases

Grants and funding

CIHR/Canada