Altered stress granule disassembly: links to neurodegenerative disease?

Trends Neurosci. 2021 Oct;44(10):765-766. doi: 10.1016/j.tins.2021.08.001. Epub 2021 Aug 21.

Abstract

A recent study by Gwon et al. identified context-specific ubiquitination of G3BP1 as critical for stress granule disassembly via VCP and the adaptor FAF2. This study provides new insights into stress granule dynamics, with potential implications for neurodegenerative disease.

Keywords: G3BP1; RNA granules; amyotrophic lateral sclerosis; frontotemporal dementia; neurodegeneration; pathomechanism.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amyotrophic Lateral Sclerosis*
  • DNA Helicases / metabolism
  • Humans
  • Neurodegenerative Diseases*
  • Poly-ADP-Ribose Binding Proteins
  • RNA Helicases / metabolism
  • RNA Recognition Motif Proteins

Substances

  • Poly-ADP-Ribose Binding Proteins
  • RNA Recognition Motif Proteins
  • DNA Helicases
  • G3BP1 protein, human
  • RNA Helicases

Grant support