A recent study by Gwon et al. identified context-specific ubiquitination of G3BP1 as critical for stress granule disassembly via VCP and the adaptor FAF2. This study provides new insights into stress granule dynamics, with potential implications for neurodegenerative disease.
Keywords: G3BP1; RNA granules; amyotrophic lateral sclerosis; frontotemporal dementia; neurodegeneration; pathomechanism.
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