Rituximab and COVID-19 vaccine can cause massive hyperacute depletion of B cells and plasma cells, as well as subsequent cytokine release syndrome, coagulopathy, and pancytopenia. These effects differ from the adverse effects that have been reported for rituximab, and new guidelines regarding the timing of rituximab infusion and vaccination are urgently needed.
Keywords: COVID‐19 vaccine; lympholysis; pancytopenia; rituximab.
© 2021 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.