Novel mRNA species from a Q-subregion class-I gene of the murine major histocompatibility complex

Gene. 1987;61(2):189-98. doi: 10.1016/0378-1119(87)90113-2.

Abstract

A novel mRNA species is specified by the Q6/Q8 gene, a member of the Qa-2-determining family of class-I genes of the murine major histocompatibility complex. It is longer than all previously described class-I transcripts due to an extension at the 3' end of the mRNA past the predicted polyadenylation site. This mRNA was detected by Northern-blot analyses with single or low-copy-number probes to the 3' end of the Q6/Q8 gene. RNase protection experiments have confirmed this finding. The appearance of this mRNA in different strains of mice correlates with the synthesis of the Qa-2 molecule.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antigens, Surface / genetics*
  • Chromosome Mapping
  • Genes, MHC Class I*
  • Histocompatibility Antigens / genetics*
  • Histocompatibility Antigens Class I*
  • Mice / genetics*
  • Molecular Weight
  • Multigene Family
  • RNA, Messenger / genetics

Substances

  • Antigens, Surface
  • Histocompatibility Antigens
  • Histocompatibility Antigens Class I
  • Q surface antigens
  • RNA, Messenger