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. 2021 Aug 19:17:851-861.
doi: 10.2147/TCRM.S324672. eCollection 2021.

The Correlation Between Low Serum T3 Levels and All-Cause and Cardiovascular Mortality in Peritoneal Dialysis Patients

Ling-Cang Xu  1   2 , Fang-Fang Zhou  1   2 , Meng Li  1   2 , Zhi-Wei Dai  1   2 , Ke-Dan Cai  1   2 , Bei-Xia Zhu  1   2 , Qun Luo  1   2
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Free PMC article

The Correlation Between Low Serum T3 Levels and All-Cause and Cardiovascular Mortality in Peritoneal Dialysis Patients

Ling-Cang Xu et al. Ther Clin Risk Manag. .
Free PMC article

Abstract

Objective: This study is to investigate the correlation between serum triiodothyronine (T3) levels and all-cause and cardiovascular mortality in PD patients.

Methods: A total of 376 end-stage renal disease (ESRD) patients who started maintenance PD treatment in the Department of Nephrology in our hospital and stable treatment for ≥3 months were selected, and the total T3 (TT3) and free T3 (FT3) levels were determined. Among them, 168 cases with FT3 <3.5 pmol/L and/or TT3 <0.92 nmol/L were divided into the low serum T3 level group, and the remaining 208 cases were divided into normal serum T3 level group. The Cox survival analysis method was used to analyze the correlation between low serum T3 levels and all-cause and cardiovascular mortality in PD patient.

Results: Compared with the normal serum T3 level group, patients with low serum T3 levels had higher systolic blood pressure and a higher proportion of heart disease, and lower levels of total T4, free T4, hemoglobin, serum albumin, blood calcium, serum total bilirubin, alanine aminotransferase, and 24-h urine volume (all P < 0.05). Binary Logistic regression analysis showed that heart disease (P = 0.003, OR: 2.628, 95% CI: 1.382-4.997) and high TT4 level (P < 0.001, OR: 0.968, 95% CI: 0.956-0.979) were related to low serum T3 levels in PD patients. Multivariate Cox regression analysis showed that low serum FT3 level was an independent risk factor for all-cause death in PD patients (HR = 0.633, 95% CI = 0.431-0.930; P < 0.020).

Conclusion: Low serum T3 levels in PD patients were associated with heart disease and TT4 levels. Low serum FT3 levels were associated with the risk of all-cause death in PD patients.

Keywords: all-cause death; cardiovascular death; correlation; peritoneal dialysis; serum T3 level.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Kaplan-Meier survival analysis of all-cause death in patients with different T3 levels.
Figure 2
Figure 2
Kaplan-Meier survival analysis of CVD death in patients with different T3 levels.
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Grants and funding

Supported by Ningbo Technology and Public Welfare Foundation, China (Grant No. 2015C50038) and Zhejiang Medical Science and Technology Research Foundation, China, (Grant No. 2020KY258).

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