Mortality in combined pulmonary fibrosis and emphysema patients is determined by the sum of pulmonary fibrosis and emphysema

An Zhao; Eyjolfur Gudmundsson; Nesrin Mogulkoc; Mark G Jones; Coline van Moorsel; Tamera J Corte; Chiara Romei; Recep Savas; Christopher J Brereton; Hendrik W van Es; Helen Jo; Annalisa De Liperi; Omer Unat; Katarina Pontoppidan; Frouke van Beek; Marcel Veltkamp; Peter Hopkins; Yuben Moodley; Alessandro Taliani; Laura Tavanti; Bahareh Gholipour; Arjun Nair; Sam Janes; Iain Stewart; David Barber; Daniel C Alexander; Athol U Wells; Joseph Jacob

doi:10.1183/23120541.00316-2021

Mortality in combined pulmonary fibrosis and emphysema patients is determined by the sum of pulmonary fibrosis and emphysema

ERJ Open Res. 2021 Aug 23;7(3):00316-2021. doi: 10.1183/23120541.00316-2021. eCollection 2021 Jul.

Authors

An Zhao¹, Eyjolfur Gudmundsson¹, Nesrin Mogulkoc², Mark G Jones³, Coline van Moorsel⁴, Tamera J Corte⁵, Chiara Romei⁶, Recep Savas⁷, Christopher J Brereton³, Hendrik W van Es⁴, Helen Jo⁵, Annalisa De Liperi⁶, Omer Unat², Katarina Pontoppidan³, Frouke van Beek⁴, Marcel Veltkamp^{8

9}, Peter Hopkins¹⁰, Yuben Moodley^{11

12}, Alessandro Taliani⁶, Laura Tavanti¹³, Bahareh Gholipour¹⁴, Arjun Nair¹⁴, Sam Janes¹⁵, Iain Stewart¹⁶, David Barber¹⁷, Daniel C Alexander¹, Athol U Wells^{18

19}, Joseph Jacob^{1

15}

Affiliations

¹ Centre for Medical Image Computing, UCL, London, UK.
² Dept of Respiratory Medicine, Ege University Hospital, Izmir, Turkey.
³ Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton and NIHR Southampton Biomedical Research Centre, University Hospital Southampton, Southampton, UK.
⁴ Dept of Radiology, St Antonius Hospital, Nieuwegein, The Netherlands.
⁵ Dept of Respiratory Medicine, Royal Prince Alfred Hospital, Camperdown, Australia.
⁶ Dept of Radiology, Pisa University Hospital, Pisa, Italy.
⁷ Dept of Radiology, Ege University Hospital, Izmir, Turkey.
⁸ Dept of Pulmonology, Interstitial Lung Diseases Center of Excellence, St Antonius Hospital, Nieuwegein, The Netherlands.
⁹ Division of Heart and Lungs, University Medical Center, Utrecht, The Netherlands.
¹⁰ Queensland Centre for Pulmonary Transplantation and Vascular Disease, The Prince Charles Hospital, Chermside, Australia.
¹¹ School of Medicine and Pharmacology, University Western Australia, Perth, Australia.
¹² Fiona Stanley Hospital, Perth, Australia.
¹³ Cardiovascular and Thoracic Dept, Pisa University Hospital, Pisa, Italy.
¹⁴ Dept of Radiology, University College London Hospitals NHS Foundation Trust, London, UK.
¹⁵ Lungs for Living Research Centre, UCL, London, UK.
¹⁶ National Heart and Lung Institute, Imperial College London, London, UK.
¹⁷ Centre for Artificial Intelligence, UCL, London, UK.
¹⁸ Dept of Respiratory Medicine, Royal Brompton Hospital, London, UK.
¹⁹ Imperial College London, London, UK.

Abstract

In patients with combined pulmonary fibrosis and emphysema, emphysema and fibrosis do not have a synergistic effect that results in worsened survival when compared to IPF patients without emphysema https://bit.ly/35EJMo6.

Grants and funding

209553/Z/17/Z/WT_/Wellcome Trust/United Kingdom