Response to mitogen-activated protein kinase inhibition of neurodegeneration in Langerhans cell histiocytosis monitored by cerebrospinal fluid neurofilament light as a biomarker: a pilot study

Jan-Inge Henter; Egle Kvedaraite; Daniel Martín Muñoz; Monica Cheng Munthe-Kaas; Bernward Zeller; Tove A Nystad; Caroline Björklund; Isabella Donnér; Magda Lourda; Henrik Zetterberg; Kaj Blennow; Nikolas Herold; Désirée Gavhed; Tatiana von Bahr Greenwood

doi:10.1111/bjh.17781

Response to mitogen-activated protein kinase inhibition of neurodegeneration in Langerhans cell histiocytosis monitored by cerebrospinal fluid neurofilament light as a biomarker: a pilot study

Br J Haematol. 2022 Jan;196(1):248-254. doi: 10.1111/bjh.17781. Epub 2021 Aug 25.

Authors

Jan-Inge Henter^{1

2}, Egle Kvedaraite^{1

3

4}, Daniel Martín Muñoz^{5

6}, Monica Cheng Munthe-Kaas⁷, Bernward Zeller⁷, Tove A Nystad⁸, Caroline Björklund⁹, Isabella Donnér¹⁰, Magda Lourda^{1

3}, Henrik Zetterberg^{11

12

13

14}, Kaj Blennow^{11

12}, Nikolas Herold^{1

2}, Désirée Gavhed^{1

2}, Tatiana von Bahr Greenwood^{1

2}

Affiliations

¹ Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
² Pediatric Oncology, Astrid Lindgrens Children's Hospital, Karolinska University Hospital, Stockholm, Sweden.
³ Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, St, Sweden.
⁴ Department of Clinical Pathology, Karolinska University Laboratory, Stockholm, Sweden.
⁵ Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
⁶ Department of Neuroradiology, Karolinska University Hospital, Stockholm, Sweden.
⁷ Department of Pediatric Hematology and Oncology, Oslo University Hospital, Oslo, Norway.
⁸ Department of Pediatrics, Division of Child and Adolescent Health, University Hospital of North-Norway, Tromsø, Norway.
⁹ Department of Pediatric Hematology and Oncology, Umeå University Hospital, Umeå, Sweden.
¹⁰ Hallands Hospital, Halmstad, Sweden.
¹¹ Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
¹² Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
¹³ UK Dementia Research Institute at UCL, London, UK.
¹⁴ Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.

No abstract available

Keywords: Langerhans cell histiocytosis; central nervous system; mitogen-activated protein kinase inhibition; neurodegeneration; neurofilament light chain protein.

Publication types

Case Reports
Letter
Research Support, Non-U.S. Gov't

MeSH terms

Biomarkers*
Child, Preschool
Disease Susceptibility
Female
Histiocytosis, Langerhans-Cell / cerebrospinal fluid*
Histiocytosis, Langerhans-Cell / diagnosis
Histiocytosis, Langerhans-Cell / drug therapy*
Histiocytosis, Langerhans-Cell / etiology
Humans
Infant
Male
Mitogen-Activated Protein Kinases / antagonists & inhibitors*
Mutation
Neurofilament Proteins / cerebrospinal fluid*
Prognosis
Protein Kinase Inhibitors / pharmacology
Protein Kinase Inhibitors / therapeutic use*
Treatment Outcome

Substances

Biomarkers
Neurofilament Proteins
Protein Kinase Inhibitors
neurofilament protein L
Mitogen-Activated Protein Kinases