Human induced pluripotent stem cell line (QBRIi013-A) derivation from a 6-year-old female diagnosed with Autism spectrum disorder (ASD) and intellectual disability (ID)

Ahmed K Elsayed; Salam Salloum-Asfar; Sara A Abdulla

doi:10.1016/j.scr.2021.102500

Human induced pluripotent stem cell line (QBRIi013-A) derivation from a 6-year-old female diagnosed with Autism spectrum disorder (ASD) and intellectual disability (ID)

Stem Cell Res. 2021 Oct:56:102500. doi: 10.1016/j.scr.2021.102500. Epub 2021 Aug 17.

Authors

Ahmed K Elsayed¹, Salam Salloum-Asfar¹, Sara A Abdulla²

Affiliations

¹ Neurological Disorders Research Center, Qatar Biomedical Research Institute, Hamad Bin Khalifa University, Qatar Foundation, PO Box 34110, Doha, Qatar.
² Neurological Disorders Research Center, Qatar Biomedical Research Institute, Hamad Bin Khalifa University, Qatar Foundation, PO Box 34110, Doha, Qatar. Electronic address: saabdulla@hbku.edu.qa.

PMID: 34438163
DOI: 10.1016/j.scr.2021.102500

Abstract

Autism spectrum disorder (ASD) is a childhood-onset neurodevelopmental disorder characterized by social interaction, behavior, and communication challenges. Here, we generated an induced pluripotent stem cell (iPSC) line, QBRIi013-A using a non-integrating Sendai virus from a 6-year-old female diagnosed with ASD and intellectual disability. The QBRIi013-A cell line was fully characterized and exhibited a pluripotency capacity and trilineage differentiation potential. Furthermore, it showed normal karyotype and genetic identity to the patient's PBMCs. Consequently, this iPSC line provides a valuable cell model in understanding the molecular mechanism underlying the complexities of ASD pathogenesis.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Autism Spectrum Disorder*
Cell Line
Child
Female
Humans
Induced Pluripotent Stem Cells*
Intellectual Disability* / genetics
Sendai virus