Increasing Area Deprivation Index negatively impacts ovarian cancer survival

Cancer Epidemiol. 2021 Oct;74:102013. doi: 10.1016/j.canep.2021.102013. Epub 2021 Aug 23.

Abstract

Introduction: While individual-level measures of socioeconomic status have been well-studied in relation to ovarian cancer survival, no studies to date have examined both state and national-level Area Deprivation Indices (ADIs), which incorporate neighborhood affluence and resources.

Methods: We abstracted clinical data from medical records for ovarian cancer cases from the Vanderbilt University Medical Center and obtained ADIs from the Neighborhood Atlas®. Associations with clinical characteristics were assessed with Spearman correlations and Kruskal-Wallis tests; associations with progression-free survival (PFS) and overall survival (OS) were assessed with Cox proportional-hazards regression.

Results: Among 184 cases, state and national ADIs were highly correlated, but not related to any cancer characteristics. In multivariable adjusted regression models, both were significantly associated with OS; each decile increase in state or national ADI corresponded to a 9 % or 10 % greater risk of death, respectively.

Conclusions: Increasing area-level deprivation may negatively impact ovarian cancer survival.

Keywords: Ovarian neoplasms; Prognosis; Socioeconomic factors; Survival.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carcinoma, Ovarian Epithelial / epidemiology
  • Female
  • Humans
  • Ovarian Neoplasms* / epidemiology
  • Progression-Free Survival
  • Proportional Hazards Models
  • Residence Characteristics
  • Social Class