COVID-19 Vaccines in Children with Cow's Milk and Food Allergies

Nutrients. 2021 Jul 30;13(8):2637. doi: 10.3390/nu13082637.


The COVID-19 pandemic is the most challenging global health crisis of our times. Vaccination against COVID-19 plays a key role to control the current pandemic situation. The risk of allergic reactions to new COVID-19 vaccines is low. However, there is a debate on the safety in allergic patients following post marketing findings by different agencies. Our aim is to understand from current experiences whether children with cow's milk or food allergy are at higher risk than a general population for allergic reactions to COVID-19 vaccines. Current data indicate that patients with a history of allergy to cow's milk or other foods, even if severe, should receive COVID-19 vaccine in a setting with availability of treatments for anaphylactic reactions and under medical supervision. Recipients should be discharged after a protracted observation period of 30 min if no reaction developed.

Keywords: COVID-19; SARS-CoV-2; anaphylaxis; cow’s milk allergy; food allergy; vaccine.

Publication types

  • Review

MeSH terms

  • Adolescent
  • Allergens / immunology
  • Anaphylaxis / etiology
  • Animals
  • COVID-19 / prevention & control*
  • COVID-19 Vaccines / adverse effects*
  • COVID-19 Vaccines / immunology
  • COVID-19 Vaccines / therapeutic use
  • Child
  • Female
  • Food Hypersensitivity / immunology*
  • Humans
  • Immunoglobulin E / immunology
  • Male
  • Milk / adverse effects
  • Milk Hypersensitivity / immunology*
  • Polyethylene Glycols / adverse effects
  • Polyethylene Glycols / therapeutic use
  • SARS-CoV-2
  • Vaccination / adverse effects


  • Allergens
  • COVID-19 Vaccines
  • Immunoglobulin E
  • Polyethylene Glycols