Sex hormones and cognitive functioning in men

Neuropsychobiology. 1987;18(1):27-36. doi: 10.1159/000118389.


Blood and saliva samples were obtained from 117 healthy young men, following which radioimmunoassays were used to determine the serum concentrations of testosterone (Tser), 5 alpha-dihydrotestosterone (DHT), and the level of free testosterone (Tsal) in the saliva. The cognitive functioning was determined by five spatial and six verbal ipsative test scores, reflecting intra-individual variance in the performance of these tasks, independent of the person's general level of achievement. Within the normal physiological range of androgen levels--especially Tser and to a lesser extent DHT and Tsal--showed a significantly positive correlation with measures of spatial ability and field dependence-independence and a significantly negative correlation with measures of verbal production.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Cognition / physiology*
  • Dihydrotestosterone / blood
  • Dihydrotestosterone / metabolism
  • Dihydrotestosterone / physiology*
  • Humans
  • Male
  • Saliva / analysis
  • Sex Characteristics
  • Testosterone / blood
  • Testosterone / metabolism
  • Testosterone / physiology*
  • Verbal Learning


  • Dihydrotestosterone
  • Testosterone