Cariostatic Efficacy of Cinnamon Water Extract on Streptococcus mutans: An In vitro Study

J Pharm Bioallied Sci. 2021 Jun;13(Suppl 1):S212-S216. doi: 10.4103/jpbs.JPBS_677_20. Epub 2021 Jun 5.


Background: Dental caries is a chronic, widespread, and infectious disease affecting the large population. Anticariogenic effects of different herbs and natural products are observed, cinnamon among these, showed the ability to inhibit Streptococcus mutans biofilm.

Objectives: The aim of this study was to assess the cinnamon water extract use on nicotine exposed S. mutans biolfilms.

Materials and methods: Microtiter plates having S. mutans culture were treated using varying nicotine concentration range (0-32 mg/ml). These were then either subjected to cinnamon water (2.5 mg/ml) extract or no treatment and analyzed using a spectrophotometer to see planktonic growth, total growth absorbance, and biofilm formation.

Results: About 2.5 mg/ml of cinnamon water inhibits the S. mutans biofilm (nicotine-induced) considerably at various nicotine levels (0-32 mg/ml).

Conclusion: Cinnamon water extract has a powerful inhibitory effect for S. mutans growth. Nicotine-induced S. mutans growth is markedly reduced by treating with cinnamon water extract.

Keywords: Biofilms; Streptococcus mutans; cinnamon water extract; nicotine.