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Observational Study
. 2022 Jun;157(3):694-701.
doi: 10.1002/ijgo.13905. Epub 2021 Sep 24.

HOMA-IR as a risk factor of gestational diabetes mellitus and a novel simple surrogate index in early pregnancy

Shuoning Song  1 , Yuemei Zhang  2 , Xiaolin Qiao  3 , Yanbei Duo  1 , Jiyu Xu  4 , Zhenyao Peng  5 , Jing Zhang  6 , Yan Chen  3 , Xiaorui Nie  3 , Qiujin Sun  7 , Xianchun Yang  7 , Zechun Lu  8 , Shixuan Liu  1 , Tianyi Zhao  1 , Tao Yuan  1 , Yong Fu  1 , Yingyue Dong  1 , Weigang Zhao  1 , Wei Sun  4 , Ailing Wang  8
Affiliations
Observational Study

HOMA-IR as a risk factor of gestational diabetes mellitus and a novel simple surrogate index in early pregnancy

Shuoning Song et al. Int J Gynaecol Obstet. 2022 Jun.

Abstract

Objective: To assess the association between insulin resistance and gestational diabetes mellitus (GDM) in early pregnancy and find a simple surrogate index of the homeostasis model assessment of insulin resistance (HOMA-IR).

Methods: A total of 700 pregnant women were included in this prospective, double-center, observational cohort study. The glucose and lipid metabolic characterization was performed at 6-12 weeks of pregnancy. All participants underwent a 75-g oral glucose tolerance test at 24-28 weeks of pregnancy. Linear regression analysis was applied to find a novel surrogate index of HOMA-IR. Binary logistic analysis was applied to estimate possible associations of different indices with GDM and insulin resistance.

Results: GDM was diagnosed in 145 of 700 women with singleton pregnancies (20.7%). HOMA-IR was higher in the GDM group than in the normal glucose tolerance (NGT) group and was an individual risk factor for GDM (adjusted risk ratio RR 1.371, 95% confidence interval [CI] 1.129-1.665, P < 0.001). TyHGB index as the surrogate index of HOMA-IR was represented as TG/HDL-C + 0.7*FBG (mmol/L) +0.1*preBMI (kg/m2 )(where TG/HDL-C is triglyceride/high-density lipoprotein cholesterol; FBG is fasting blood glucose, and preBMI is the pre-pregnancy body mass index [calculated as weight in kilograms divided by the square of height in meters]). The cut-off point of the TyHGB index was 6.0 (area under the curve 0.827, 95% CI 0.794-0.861, P < 0.001) for mild insulin resistance.

Conclusion: Increased HOMA-IR in early pregnancy was a risk factor of GDM. TyHGB index could be a surrogate index of HOMA-IR and had a predictive value for GDM.

Keywords: HOMA-IR; gestational diabetes mellitus; glucose and lipid metabolism; insulin resistance.

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References

REFERENCES

    1. Landon MB, Gabbe SG. Gestational diabetes mellitus. Obstet Gynecol. 2011;118(6):1379-1393.
    1. Zhu Y, Zhang C. Prevalence of gestational diabetes and risk of progression to type 2 diabetes: a global perspective. Curr Diab Rep. 2016;16(1):7.
    1. Damm P, Houshmand-Oeregaard A, Kelstrup L, Lauenborg J, Mathiesen ER, Clausen TD. Gestational diabetes mellitus and long-term consequences for mother and offspring: a view from Denmark. Diabetologia. 2016;59(7):1396-1399.
    1. Lacroix M, Kina E, Hivert MF. Maternal/fetal determinants of insulin resistance in women during pregnancy and in offspring over life. Curr Diab Rep. 2013;13(2):238-244.
    1. Temming LA, Tuuli MG, Stout MJ, Macones GA, Cahill AG. Maternal and perinatal outcomes in women with insulin resistance. Am J Perinatol. 2016;33(8):776-780.

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