Not All Hepatocellular Adenomas are Caused by the Hormonal Oral Contraceptive

S D Med. 2021 Jul;74(7):302-303.


This is a case report of a female patient with multiple hepatocellular adenomas secondary to the glycogen storage disease 1a with asymptomatic and late adult-onset presentation. Even though the patient was taking a hormonal oral contraceptive, it was important to identify the genetic disorder and ensure adequate metabolic control which is considered a modifier of the adenoma formation and progression. It is also imperative that the patient gets monitored for the adenoma-to-hepatocellular carcinoma transformation.

Publication types

  • Case Reports

MeSH terms

  • Adenoma*
  • Adenoma, Liver Cell* / chemically induced
  • Adenoma, Liver Cell* / diagnostic imaging
  • Adult
  • Carcinoma, Hepatocellular* / chemically induced
  • Contraceptives, Oral, Hormonal / adverse effects
  • Female
  • Humans
  • Liver Neoplasms* / chemically induced


  • Contraceptives, Oral, Hormonal