Focal Epithelial Hyperplasia

Viruses. 2021 Aug 2;13(8):1529. doi: 10.3390/v13081529.


Focal epithelial hyperplasia (FEH) or Heck's disease is a rare, benign, oral condition that is associated with infection by human papillomavirus type 13, 32 or both. The whiteish to mucosal-colored, soft, papular or nodular elevated lesions in the oral cavity are normally asymptomatic but can grow to a size or at a location where treatment is needed. The diagnosis is often based on clinical presentation and histopathology, and the HPV genotype can be determined using PCR utilizing specific primers or DNA sequencing. While FEH was reported to often affect several members of the same family and exist primarily among indigenous populations around the world, the number of reported cases within the European region is increasing. This contemporary review summarizes the main findings in relation to HPV genotypes, impact of superinfection exclusion and vaccination, transmission, diagnosis, geographical and ethnical distribution, comorbidities and treatment of FEH with an emphasis on including the most recent case reports within the field. Furthermore, we describe for the first time a FEH lesion infected with the low-risk HPV90.

Keywords: FEH; HPV13; HPV32; Heck’s disease; MEH; focal epithelial hyperplasia; human papillomavirus 13; human papillomavirus 32; multifocal epithelial hyperplasia.

Publication types

  • Editorial

MeSH terms

  • Alphapapillomavirus / classification
  • Alphapapillomavirus / genetics*
  • Alphapapillomavirus / pathogenicity*
  • Focal Epithelial Hyperplasia*
  • Genotype
  • Humans
  • Papillomavirus Infections / complications*
  • Papillomavirus Infections / prevention & control
  • Papillomavirus Infections / transmission
  • Risk Factors