How does the convergence of prematurity and congenital heart disease impact the developing brain?

Dawn Gano; Patrick McQuillen

doi:10.1016/j.semperi.2021.151472

How does the convergence of prematurity and congenital heart disease impact the developing brain?

Semin Perinatol. 2021 Nov;45(7):151472. doi: 10.1016/j.semperi.2021.151472. Epub 2021 Aug 20.

Authors

Dawn Gano¹, Patrick McQuillen²

Affiliations

¹ Department of Neurology, University of California, San Francisco, United States; Department of Pediatrics, University of California, San Francisco, United States. Electronic address: Dawn.Gano@ucsf.edu.
² Department of Pediatrics, University of California, San Francisco, United States.

PMID: 34452752
DOI: 10.1016/j.semperi.2021.151472

Abstract

Prematurity and congenital heart disease (CHD) are individually associated with increased risk of brain injury and adverse neurodevelopmental outcomes. Delayed brain development in newborns with CHD has been documented to begin in utero and predisposes newborns with CHD to brain injury. Little is known about the combined risks when prematurity and CHD co-occur. The purpose of this review is to highlight the unique vulnerability of preterm newborns with CHD to brain dysmaturation and brain injury, and the urgent need for prospective research.

Keywords: Brain injury; Congenital heart defects; Magnetic resonance imaging; Preterm.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Brain
Brain Injuries*
Heart Defects, Congenital* / complications
Humans
Infant, Newborn
Magnetic Resonance Imaging
Prospective Studies

Grants and funding

P01 NS082330/NS/NINDS NIH HHS/United States