Not just a 'drain': venules sprout brain capillaries

Trends Neurosci. 2021 Nov;44(11):849-851. doi: 10.1016/j.tins.2021.08.004. Epub 2021 Aug 24.


The cerebral cortex requires a dense, highly organized network of vasculature that ensures high-volume and continuous oxygen delivery to metabolically active neuronal circuits. In a recent paper, Coelho-Santos et al. used in vivo two-photon microscopy to reveal how this precise network is constructed during a short window of mouse postnatal development.

Keywords: brain angiogenesis; brain development; capillary; cerebrovasculature; neurovascular unit; pericyte.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Brain / blood supply
  • Capillaries*
  • Cerebral Cortex
  • Humans
  • Mice
  • Pericytes*
  • Venules