A review of hydrogel systems based on poly(N-isopropyl acrylamide) for use in the engineering of bone tissues

Saeid Shabestari Khiabani; Marziyeh Aghazadeh; Jamshid Rakhtshah; Soodabeh Davaran

doi:10.1016/j.colsurfb.2021.112035

A review of hydrogel systems based on poly(N-isopropyl acrylamide) for use in the engineering of bone tissues

Colloids Surf B Biointerfaces. 2021 Dec:208:112035. doi: 10.1016/j.colsurfb.2021.112035. Epub 2021 Aug 14.

Authors

Saeid Shabestari Khiabani¹, Marziyeh Aghazadeh², Jamshid Rakhtshah³, Soodabeh Davaran⁴

Affiliations

¹ Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
² Oral Medicine Department of Dental Faculty, Tabriz University of Medical Sciences, Tabriz, Iran.
³ Department of Medical Nanotechnology, Faculty of Advanced Medical Science, Tabriz University of Medical Sciences, Tabriz, Iran.
⁴ Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran; Health Innovation Acceleration Center of Tabriz University of Medical Science and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: davaran@tbzmed.ac.ir.

PMID: 34455315
DOI: 10.1016/j.colsurfb.2021.112035

Abstract

Bone fracture is usually a medical condition where occurred by high force impact or stress. Recent advances to repair damaged or diseased bone tissues employs three-dimensional (3D) polymer matrices. This review aims to investigate the potential of injectable, dual thermally, and chemically gelable N-isopropyl acrylamide-based hydrogels to deliver scaffold, cells, and growth factors in vitro and in vivo.

Keywords: Bone; Crosslinking; Hydrogel; Poly(N-isopropyl acrylamide); Tissue engineering.

Publication types

Review

MeSH terms

Acrylamides
Bone and Bones
Hydrogels*
Polymers
Tissue Engineering*

Substances

Acrylamides
Hydrogels
Polymers