Rational design of a stapled JAZ9 peptide inhibiting protein-protein interaction of a plant transcription factor

RSC Chem Biol. 2021 Jan 5;2(2):499-502. doi: 10.1039/d0cb00204f. eCollection 2021 Apr 1.


We herein describe the development of a stapled peptide inhibitor for a jasmonate-related transcription factor. The designed peptide selectively inhibited MYCs, master-regulators of jasmonate signaling, and selectively suppressed MYC-mediated gene expression in Arabidopsis thaliana. It is proposed as a novel chemical tool for the analysis of MYC related jasmoante signaling.