Clinicopathological analysis of primary carcinoid tumour of the ovary arising in mature cystic teratomas

J Int Med Res. 2021 Aug;49(8):3000605211034666. doi: 10.1177/03000605211034666.

Abstract

Objective: To investigate the clinicopathological features, diagnosis and differential diagnosis of patients with primary ovarian carcinoid tumours arising in mature cystic teratomas.

Methods: This retrospective case series analysed the data from patients with primary ovarian carcinoid tumours arising in mature cystic teratomas.

Results: The study enrolled four patients. Histopathological analysis of the tumours identified the following subtypes: insular (n = 1), trabecular (n = 1) and strumal (n = 2). All four primary ovarian carcinoid tumours originated from a mature teratoma. The morphology of the primary ovarian carcinoids was similar to other neuroendocrine tumours. Strumal carcinoids were composed of different proportions of thyroid tissue intimately admixed with carcinoid tumour. Tumour tissue was arranged in insular and/or trabecular patterns. The nucleus of tumour cells displayed exquisite chromatin without obvious mitotic figures. Tumour tissues were positively stained for neuroendocrine markers chromogranin A, synaptophysin and CD56 to varying degrees. Strumal carcinoid tumours were cytokeratin 19 positive and thyroid transcription factor 1 negative. No recurrence or metastasis occurred during follow-up (12-71 months).

Conclusion: Primary ovarian carcinoid tumours arising in mature cystic teratomas are rare. Diagnosis and differential diagnosis should be confirmed by clinical features, histopathological characteristics and specific immunophenotyping.

Keywords: Carcinoid tumour; immunohistochemistry; neuroendocrine; ovarian; teratoma.

MeSH terms

  • Carcinoid Tumor* / diagnosis
  • Female
  • Humans
  • Neoplasm Recurrence, Local
  • Ovarian Neoplasms* / diagnosis
  • Retrospective Studies
  • Struma Ovarii* / diagnosis
  • Teratoma* / diagnosis