Fatal Systemic Capillary Leak Syndrome after SARS-CoV-2Vaccination in Patient with Multiple Myeloma

Emerg Infect Dis. 2021 Nov;27(11):2973-2975. doi: 10.3201/eid2711.211723. Epub 2021 Aug 30.


A young man with smoldering multiple myeloma died of hypotensive shock 2.5 days after severe acute respiratory syndrome coronavirus 2 vaccination. Clinical findings suggested systemic capillary leak syndrome (SCLS); the patient had experienced a previous suspected flare episode. History of SCLS may indicate higher risk for SCLS after receiving this vaccine.

Keywords: Ad26.COV2.S; COVID-19; COVID-19 vaccine; Clarkson disease; SARS-CoV-2; coronavirus disease; monoclonal gammopathy; multiple myeloma; respiratory infections; severe acute respiratory syndrome coronavirus 2; systemic capillary leak syndrome; vaccines; viruses.

MeSH terms

  • COVID-19*
  • Capillary Leak Syndrome* / chemically induced
  • Capillary Leak Syndrome* / diagnosis
  • Humans
  • Male
  • Multiple Myeloma* / complications
  • SARS-CoV-2
  • Severe acute respiratory syndrome-related coronavirus*