Mutations Associated with SARS-CoV-2 Variants of Concern, Benin, Early 2021

Emerg Infect Dis. 2021 Nov;27(11):2889-2903. doi: 10.3201/eid2711.211353. Epub 2021 Aug 31.


Intense transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Africa might promote emergence of variants. We describe 10 SARS-CoV-2 lineages in Benin during early 2021 that harbored mutations associated with variants of concern. Benin-derived SARS-CoV-2 strains were more efficiently neutralized by antibodies derived from vaccinees than patients, warranting accelerated vaccination in Africa.

Keywords: Benin; COVID-19; SARS-CoV-2; West Africa; coronavirus disease; mutations; respiratory infections; severe acute respiratory syndrome coronavirus 2; variant of concern; viruses; zoonoses.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benin / epidemiology
  • COVID-19*
  • Humans
  • Mutation
  • SARS-CoV-2*