Unravelling the mystery of female meiotic drive: where we are

Open Biol. 2021 Sep;11(9):210074. doi: 10.1098/rsob.210074. Epub 2021 Sep 1.


Female meiotic drive is the phenomenon where a selfish genetic element alters chromosome segregation during female meiosis to segregate to the egg and transmit to the next generation more frequently than Mendelian expectation. While several examples of female meiotic drive have been known for many decades, a molecular understanding of the underlying mechanisms has been elusive. Recent advances in this area in several model species prompts a comparative re-examination of these drive systems. In this review, we compare female meiotic drive of several animal and plant species, highlighting pertinent similarities.

Keywords: chromosome segregation; female meiosis; meiotic drive; selfish genetic elements.

Publication types

  • Research Support, N.I.H., Intramural
  • Review

MeSH terms

  • Animals
  • Centromere / genetics*
  • Chromosome Segregation*
  • Female
  • Meiosis*
  • Plants