Cross-reactive CD4 + T cells enhance SARS-CoV-2 immune responses upon infection and vaccination

Science. 2021 Oct 8;374(6564):eabh1823. doi: 10.1126/science.abh1823. Epub 2021 Oct 8.

Abstract

[Figure: see text].

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Asymptomatic Diseases
  • CD3 Complex / immunology
  • CD4-Positive T-Lymphocytes / immunology*
  • COVID-19 / immunology*
  • COVID-19 Vaccines / immunology
  • Cross Reactions
  • Female
  • Humans
  • Immunity
  • Immunodominant Epitopes / immunology
  • Male
  • Middle Aged
  • Open Reading Frames
  • Peptide Fragments / immunology
  • SARS-CoV-2 / genetics
  • SARS-CoV-2 / immunology*
  • Spike Glycoprotein, Coronavirus / immunology
  • Vaccination
  • Young Adult

Substances

  • CD3 Complex
  • COVID-19 Vaccines
  • Immunodominant Epitopes
  • Peptide Fragments
  • Spike Glycoprotein, Coronavirus
  • spike protein, SARS-CoV-2
  • BNT162 vaccine