Immunopathogenic mechanisms of rheumatoid arthritis and the use of anti-inflammatory drugs

Intractable Rare Dis Res. 2021 Aug;10(3):154-164. doi: 10.5582/irdr.2021.01022.


Rheumatoid arthritis (RA) is a chronic, progressive autoimmune disease characterized by synovitis and symmetrical joint destruction. RA has become one of the key diseases endangering human health, but its etiology is not clear. Therefore, identifying the immunopathogenic mechanisms of RA and developing therapeutic drugs to treat autoimmune diseases have always been difficult. This article mainly reviews the immunopathogenic mechanism of RA and advances in the study of anti-inflammatory drugs in order to provide a reference for the treatment of RA and drug development in the future.

Keywords: cytokines; immunopathogenesis; inflammatory drugs; rheumatoid arthritis.

Publication types

  • Review