Aspergillus lentulus: An Under-recognized Cause of Antifungal Drug-Resistant Aspergillosis

Open Forum Infect Dis. 2021 Aug 29;8(8):ofab392. doi: 10.1093/ofid/ofab392. eCollection 2021 Aug.


Aspergillus lentulus is a drug-resistant species that is phenotypically similar to A. fumigatus. It was discovered as a cause of azole-breakthrough disease, consistent with in vitro resistance. Clinical labs can misidentify the species as fumigatus based on phenotypic typing. We describe 4 recent cases and provide a brief review.

Keywords: Aspergillus lentulus; DNA sequencing; MALDI-TOF MS; cryptic species; multidrug resistance; pulmonary aspergillosis.