A protein regulated by UBE3A PEGs a potential biomarker

Noelle D Germain; Stormy J Chamberlain

doi:10.1016/j.xcrm.2021.100377

A protein regulated by UBE3A PEGs a potential biomarker

Cell Rep Med. 2021 Aug 17;2(8):100377. doi: 10.1016/j.xcrm.2021.100377.

Authors

Noelle D Germain¹, Stormy J Chamberlain^{1

2}

Affiliations

¹ Department of Genetics and Genome Sciences, UConn Health, Farmington, CT 06030, USA.
² Institute for Systems Genomics, University of Connecticut, Storrs, CT 06269, USA.

Abstract

New research from Pandya and colleagues¹ identifies PEG10 as a UBE3A-regulated protein that may underlie pathophysiology in Angelman syndrome neurons. PEG10 is a secreted protein, and this work suggests that it may be a potential biomarker for Angelman syndrome therapeutics under development.

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MeSH terms

Angelman Syndrome* / genetics
Animals
Biomarkers
Disease Models, Animal
Neurons
Ubiquitin-Protein Ligases* / genetics

Substances

Biomarkers
Ubiquitin-Protein Ligases