Chiroptical materials with circularly polarized luminescence (CPL) activity have aroused a lot of interest. One essential factor for evaluating the features of CPL-active materials is the dissymmetry factor (glum), which represents the circular polarization of emitted light. Essentially, for the practical application of CPL, the most important issue is to greatly improve the glum value. Recently, benefiting from the flexible and efficient design in hybrid donor-acceptor systems, more and more examples involving glum value amplification have been reported. In this Perspective, we highlight the proposed mechanism for the generation and amplification of CPL in these hybrid systems. We also present the corresponding design principles and potential pitfalls in experimental processes. We hope that this Perspective can shed light on the development of highly efficient CPL-active materials.